Tert-butyl 3-[2-hydroxy-4-oxo-8-[(4-propan-2-yl-1,3-thiazol-2-yl)methoxy]pyrido[1,2-a]pyrimidin-3-yl]prop-2-enoate → Tert-butyl 3-[8-[(4-tert-butyl-1,3-thiazol-2-yl)carbamoyl]-2-(3-hydroxypiperidin-1-yl)-4-oxopyrido[1,2-a]pyrimidin-3-yl]prop-2-enoate

HRID 837255Notes

Reaction equation

HRID 837255 reaction equation
[C:32]([CH3:33])([CH3:34])([CH3:35])[c:36]1[n:37][c:38]([NH:41][C:42](=[O:43])[c:44]2[cH:45][c:46]3[n:47]([c:48](=[O:70])[c:49]([CH:61]=[CH:62][C:63](=[O:64])[O:65][C:66]([CH3:67])([CH3:68])[CH3:69])[c:50]([N:52]4[CH2:53][CH:54]([O:58][CH:59]=[O:60])[CH2:55][CH2:56][CH2:57]4)[n:51]3)[cH:71][cH:72]2)[s:39][cH:40]1.[OH:1][c:2]1[n:3][c:4]2[cH:5][c:6]([O:7][CH2:8][c:9]3[s:10][cH:11][c:12]([CH:13]([CH3:14])[CH3:15])[n:16]3)[cH:17][cH:18][n:19]2[c:20](=[O:21])[c:22]1[CH:23]=[CH:24][C:25]([O:26][C:27]([CH3:28])([CH3:29])[CH3:30])=[O:31]>>[C:32]([CH3:33])([CH3:34])([CH3:35])[c:36]1[n:37][c:38]([NH:41][C:42](=[O:43])[c:44]2[cH:45][c:46]3[n:47]([c:48](=[O:70])[c:49]([CH:61]=[CH:62][C:63](=[O:64])[O:65][C:66]([CH3:67])([CH3:68])[CH3:69])[c:50]([N:52]4[CH2:53][CH:54]([OH:58])[CH2:55][CH2:56][CH2:57]4)[n:51]3)[cH:71][cH:72]2)[s:39][cH:40]1

Participants

3

Reactant 2

HCID 136618853Tert-butyl 3-[2-hydroxy-4-oxo-8-[(4-propan-2-yl-1,3-thiazol-2-yl)methoxy]pyrido[1,2-a]pyrimidin-3-yl]prop-2-enoateHCID 178450931HCID 178450931, compound

Product 1

HCID 90746462Tert-butyl 3-[8-[(4-tert-butyl-1,3-thiazol-2-yl)carbamoyl]-2-(3-hydroxypiperidin-1-yl)-4-oxopyrido[1,2-a]pyrimidin-3-yl]prop-2-enoate

Sources & evidence

ORD record
ord-115d2855e65344d293d3bd7fbe8884e3
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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