1-(4-amino-3-methoxyphenyl)-N,N-dimethylpiperidin-4-amine → N-(4-(4-(Dimethylamino)piperidin-1-yl)-2-methoxyphenyl)-5-fluoro-4-(1H-indol-3-yl)pyrimidin-2-amine

HRID 837404Notes

Reaction equation

HRID 837404 reaction equation
[Cl:1][c:2]1[n:3][cH:4][c:5]([F:17])[c:6](-[c:8]2[cH:9][nH:10][c:11]3[cH:12][cH:13][cH:14][cH:15][c:16]23)[n:7]1.[NH2:18][c:19]1[c:20]([O:34][CH3:35])[cH:21][c:22]([N:25]2[CH2:26][CH2:27][CH:28]([N:31]([CH3:32])[CH3:33])[CH2:29][CH2:30]2)[cH:23][cH:24]1>>[c:2]1([NH:18][c:19]2[c:20]([O:34][CH3:35])[cH:21][c:22]([N:25]3[CH2:26][CH2:27][CH:28]([N:31]([CH3:32])[CH3:33])[CH2:29][CH2:30]3)[cH:23][cH:24]2)[n:3][cH:4][c:5]([F:17])[c:6](-[c:8]2[cH:9][nH:10][c:11]3[cH:12][cH:13][cH:14][cH:15][c:16]23)[n:7]1

Participants

3

Reactant 2

HCID 574161531-(4-amino-3-methoxyphenyl)-N,N-dimethylpiperidin-4-amineHCID 580714353-(2-chloro-5-fluoropyrimidin-4-yl)-1H-indole

Product 1

HCID 58071447N-(4-(4-(Dimethylamino)piperidin-1-yl)-2-methoxyphenyl)-5-fluoro-4-(1H-indol-3-yl)pyrimidin-2-amine

Sources & evidence

ORD record
ord-935f2a6719ec454db101166f323b8074
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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