p,p'-Dimethoxybenzhydryl alcohol → 4-(4,4'-Dimethoxybenzhydryl)-thiophenyl boronic acid

HRID 83745Notes

Reaction equation

HRID 83745 reaction equation
[CH3:1][O:2][C:3]1[CH:18]=[CH:17][C:6]([CH:7](O)[C:8]2[CH:13]=[CH:12][C:11]([O:14][CH3:15])=[CH:10][CH:9]=2)=[CH:5][CH:4]=1.[SH:19][C:20]1C=C[C:23]([B:26]([OH:28])[OH:27])=[CH:22][CH:21]=1>CC(O)=O>[CH3:1][O:2][C:3]1[CH:18]=[CH:17][C:6]([CH:7]([C:21]2[CH:22]=[C:23]([B:26]([OH:28])[OH:27])[S:19][CH:20]=2)[C:8]2[CH:13]=[CH:12][C:11]([O:14][CH3:15])=[CH:10][CH:9]=2)=[CH:5][CH:4]=1

Participants

4

Reactant 2

HCID 69768p,p'-Dimethoxybenzhydryl alcoholHCID 44318944-Mercaptophenylboronic acid

Product 1

HCID 671206874-(4,4'-Dimethoxybenzhydryl)-thiophenyl boronic acid

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Conditions

Temperature
60 °C

Procedure

4,4′-Dimethoxybenzhydrol (2.7 g, 11 mmol) and 4-mercaptophenylboronic acid (1.54 g, 10 mmol) were dissolved in AcOH (20 mL) and heated at 60° C. for 1 h. Solvent was evaporated and the residue was dried under high vacuum. This material was used without further purification.

Workup

  1. customSolvent was evaporated
  2. customthe residue was dried under high vacuum
  3. customThis material was used without further purification

Sources & evidence

ORD record
ord-e2e7acdfffb3445a9d9ce32b74f6c004
Source dataset
uspto-grants-2014_09
Patent number
US08846753B2

Reaction notes

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