5-Bromo-thiophene-2-sulfonic acid bis-(2-hydroxy-ethyl)-amide → 5-[7-Difluoromethyl-5-(4-trifluoromethyl-phenyl)-pyrazolo[1,5-a]pyrimidin-3-ylethynyl]-thiophene-2-sulfonic acid bis-(2-hydroxy-ethyl)-amide
Reaction equation
[F:1][CH:2]([c:3]1[cH:4][c:5](-[c:14]2[cH:15][cH:16][c:17]([C:20]([F:21])([F:22])[F:23])[cH:18][cH:19]2)[n:6][c:7]2[n:8]1[n:9][cH:10][c:11]2[C:12]#[CH:13])[F:24].[OH:25][CH2:26][CH2:27][N:28]([S:29](=[O:30])(=[O:31])[c:32]1[s:33][c:34]([Br:37])[cH:35][cH:36]1)[CH2:38][CH2:39][OH:40]>>[F:1][CH:2]([c:3]1[cH:4][c:5](-[c:14]2[cH:15][cH:16][c:17]([C:20]([F:21])([F:22])[F:23])[cH:18][cH:19]2)[n:6][c:7]2[n:8]1[n:9][cH:10][c:11]2[C:12]#[C:13][c:34]1[s:33][c:32]([S:29]([N:28]([CH2:27][CH2:26][OH:25])[CH2:38][CH2:39][OH:40])(=[O:30])=[O:31])[cH:36][cH:35]1)[F:24]Participants
3
Reactant 2
Product 1
Sources & evidence
- ORD record
- ord-2b716aa5d4354898b3aab35dcf04ecc5
- Source dataset
- Test data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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