6-(4-Isocyanatophenoxy)-hexanoic acid methyl ester → HCID 59253952, compound

Participants

Reaction Conditions

Reaction Steps

To a mixture of 6-[4-(2-hydroxyethoxycarbonylamino)phenoxy]hexanoic acid methyl ester 19 (5 g, 15.38 mmol) in toluene (50 ml) was added 6-(4-isocyanatophenoxy)-hexanoic acid methyl ester 18 (4 g, 15.2 mmol) at room temperature and heated to 60° C. for 2 hours. Toluene was distilled and water (50 ml) was added. The solid was filtered and dried to give crude 20, which was purified by column chromatography on silica gel using chloroform as eluant to get pure 20 (8.5 g, 94%) as a white powder with an m.p. between 118-120.5° C.

Provenance & Evidence