反应详情

2-(4-Nitrophenoxy) propionic acid methyl ester 14 (50 g) and concen. HCl (500 ml) were refluxed for 8 hours. The reaction mass was cooled to room temperature. Crude 29 was filtered, dried and recrystallised from a mixture of ethyl acetate:hexane (1:5) to give pure 29 (40 g, 85.3%) as a white powder with an m.p. between 139-141° C.

1. filtrationCrude 29 was filtered
2. customdried
3. customrecrystallised from a mixture of ethyl acetate:hexane (1:5)