ethyl [4-bromo-3-(6-hydroxy-2,2-dimethyl-2,3-dihydro-1-benzofuran-5-yl)-3-(hydroxymethyl)-2-oxo-2,3-dihydro-1H-indol-1-yl]acetate → ethyl (4'-bromo-6,6-dimethyl-2'-oxo-5,6-dihydrospiro[benzo[1,2-b:5,4-b']difuran-3,3'-indol]-1'(2'H)-yl)acetate

HRID 838060Notes

Reaction equation

HRID 838060 reaction equation
[Br:1][c:2]1[c:3]2[c:7]([cH:8][cH:9][cH:10]1)[N:6]([CH2:11][C:12](=[O:13])[O:14][CH2:15][CH3:16])[C:5](=[O:17])[C:4]2([CH2:18][OH:19])[c:20]1[c:21]([OH:31])[cH:22][c:23]2[c:24]([cH:30]1)[CH2:25][C:26]([CH3:28])([CH3:29])[O:27]2.[CH:32]1([CH2:33][CH2:34][N:35]2[c:36]3[c:37]([cH:38][cH:39][cH:40][cH:41]3)[C:42]([c:43]3[c:44]([OH:45])[cH:46][c:47]4[c:51]([cH:52]3)[O:50][CH2:49][O:48]4)([CH2:53][OH:54])[C:55]2=[O:56])[CH2:57][CH2:58]1>>[Br:1][c:2]1[c:3]2[c:7]([cH:8][cH:9][cH:10]1)[N:6]([CH2:11][C:12](=[O:13])[O:14][CH2:15][CH3:16])[C:5](=[O:17])[C:4]21[CH2:18][O:31][c:21]2[c:20]1[cH:30][c:24]1[c:23]([cH:22]2)[O:27][C:26]([CH3:28])([CH3:29])[CH2:25]1

Participants

3

Reactant 2

HCID 58872464ethyl [4-bromo-3-(6-hydroxy-2,2-dimethyl-2,3-dihydro-1-benzofuran-5-yl)-3-(hydroxymethyl)-2-oxo-2,3-dihydro-1H-indol-1-yl]acetateHCID 666425671-(2-cyclopropylethyl)-3-(6-hydroxy-1,3-benzodioxol-5-yl)-3-(hydroxymethyl)-1,3-dihydro-2H-indol-2-one

Product 1

HCID 59263323ethyl (4'-bromo-6,6-dimethyl-2'-oxo-5,6-dihydrospiro[benzo[1,2-b:5,4-b']difuran-3,3'-indol]-1'(2'H)-yl)acetate

Sources & evidence

ORD record
ord-0f30bcda944144bca3031f8092e60d1e
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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