Pyridine → HCID 20324728, compound

HRID 838801Notes

Reaction equation

HRID 838801 reaction equation
[N:1]1C=CC=CC=1.Br.[Br:8][CH2:9][CH2:10]N.[Cl:12][CH2:13][S:14](Cl)(=[O:16])=[O:15]>C(Cl)(Cl)Cl>[Br:8][CH2:9][CH2:10][CH:13]([Cl:12])[S:14]([NH2:1])(=[O:16])=[O:15]

Participants

5

Reactant 3

HCID 1049PyridineHCID 77054(Chloromethyl)sulfonyl chlorideHCID 27742172-Bromoethylamine hydrobromide

Product 1

HCID 20324728HCID 20324728, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

Pyridine (17.8 ml.) was added over a period of 30 minutes to a cooled solution (15°-20° C.) of 2-bromoethylamine hydrobromide (20.5 g., 0.10 mole) and chloromethanesulfonyl chloride (14.9 g., 0.10 mole) in chloroform. The mixture was stirred for 1 hour and then washed with water (100 ml.) and dilute hydrochloric acid (50 ml.). The solution was dried over magnesium sulfate. The solvent was evaporated in vacuo. There was obtained 10 g. of a dark oil, the title compound. Structure was confirmed by infrared analysis.

Workup

  1. washwashed with water (100 ml.) and dilute hydrochloric acid (50 ml.)
  2. dry with materialThe solution was dried over magnesium sulfate
  3. customThe solvent was evaporated in vacuo
  4. customThere was obtained 10 g

Sources & evidence

ORD record
ord-a4fcc40e59aa4b7eafcd961261811854
Source dataset
uspto-grants-1978_06
Patent number
US04093445

Reaction notes

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