反应详情

A mixture of 5-t-butyl-1,3,4-thiadiazol-2yl isocyanate dimer (8.7 grams), the diethyl acetal of 2-allylaminoacetaldehyde (8.0 grams) and benzene (50 ml) was charged into a glass reaction flask equipped with a mechanical stirrer and thermometer. The reaction mixture was then warmed with stirring until the reactants dissolved. After this time the reaction mixture was stripped of benzene to yield an oil. This oil was dissolved in an ether-pentane mixture and was treated with diatomaceous earth and filtered. The filtrate was then stripped of solvent to yield the desired product the diethyl acetal of 2-[1-allyl-3-(5-t-butyl-1,3,4-thiadiazol-2-yl)ureido]acetaldehyde as a dark red oil.

1. customequipped with a mechanical stirrer
2. temperatureThe reaction mixture was then warmed
3. dissolutiondissolved
4. customto yield an oil
5. additionwas treated with diatomaceous earth
6. filtrationfiltered