化工社化工社 化学情報印刷レポート · 研究参考用
p-Toluenesulfonic acid → 3-isopropyl-3-methyl-3H-imidazo[2,1-a]isoindole-2,5-dione
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | p-Toluenesulfonic acid | HCID 6101 | — |
| 反応物 | Potassium Hydroxide | HCID 14797 | — |
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | Sodium hydride | HCID 24758 | — |
| 反応物 | 1,1,3,3-Tetramethylguanidine | HCID 66460 | — |
| 反応物 | Diisopropylethylamine | HCID 81531 | — |
| 反応物 | Barium Oxide Nanoparticle Dispersion | HCID 9855530 | — |
| 反応物 | Tetramethylbenzyl ammonium hydroxide | HCID 19860286 | — |
| 生成物 | 3-isopropyl-3-methyl-3H-imidazo[2,1-a]isoindole-2,5-dione | HCID 2729247 | — |
反応手順
The above procedure is repeated in all respects, excepting that the strong base reagent is altered. In separate experiments, sodium hydride, potassium hydroxide, barium oxide, diisopropylethylamine, 1,5-diazobicyclo[5.4.0]undicene-5, tetramethylguanidine, tetramethylbenzyl ammonium hydroxide, Amberlite A21 (Rohm & Haas) strongly basic ion exchange resin and p-toluenesulfonic acid, are substituted for sodium hydroxide and yield the desired 3-isopropyl-3-methyl-5H-imidazo[2,1-a]isoindole-2(3H),5-dione. In practice of the above-described method, sodium hydroxide or sodium hydride in refluxing toluene is preferred.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04093441 |
| 出典データセット | uspto-grants-1978_06 |
| ORD ID | ord-d3c6b7a46a284581abc85b3696067c4a |
| 出典メモ | uspto-grants-1978_06 |