Hydrochloric Acid → HCID 20318415, compound

Participants

Reaction Steps

Under nitrogen, a solution of methyl 3-(5-tert.-butyl-2,3-dimethyl-4 -hydroxyphenyl)propionate (71.5 g) in 150 ml of ethanol was treated with a solution of 98% sodium hydroxide (12.1 g) in 15 ml of water, and the mixture was heated under reflux for 3 hours. The cold solution was diluted with water to about 1200 ml and then acidified with concentrated hydrochloric acid. The precipitated solid was filtered off and washed with water. Recrystallization from 600 ml of acetonitrile gave the acid, m.p. 191° to 193° C.

Provenance & Evidence