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HRID838896

反应详情

EQUATION

反应方程式

HRID 838896 的结构方程式

REACTANTS

反应物

2
结构：CNC
HCID674

Dimethylamine

C2H7N

结构：CC1(C)CC(c2ccccc2)c2ccc(OCC3CO3)cc2O1
HCID23330756

未命名化合物

PRODUCTS

生成物

1
结构：CN(C)CC(O)COc1ccc2c(c1)OC(C)(C)CC2c1ccccc1
HCID3046428

未命名化合物

收率 97%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CCO
溶剂HCID702

Ethanol

C2H6O

PROCEDURE

实验过程

A mixture of 7-(2,3-epoxypropoxy)-2,2-dimethyl-4-phenylchroman (6.1g), anhydrous dimethylamine (15ml) and ethanol were left to stand at ambient temperature until tlc showed that reaction was complete (c. 2hrs.). Removal of the solvent in vacuo gave 7-(2-hydroxy-3-dimethylaminopropoxy)-2,2-dimethyl-4-phenylchroman (6.8g, 97%) isolated as the hydrochloride salt, m.p. 210°-215°, from acetone-ethanol.

WORKUP

后处理

  1. waitwere left
  2. customto stand at ambient temperature until tlc
  3. customshowed that reaction
  4. custom(c. 2hrs.)
  5. customRemoval of the solvent in vacuo