HuagongsheHuagongshe Chemistry Print Report · For research reference only
Isopropylamine → 7-(2-Hydroxy-3-isopropylaminopropoxy)-2,2-dimethyl-4-phenylchroman
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Isopropylamine | HCID 6363 | — |
| Reactant | 7-(2,3-Epoxypropoxy)-2,2-dimethyl-4-phenylchroman | HCID 23330756 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 7-(2-Hydroxy-3-isopropylaminopropoxy)-2,2-dimethyl-4-phenylchroman | HCID 3046430 | 73% |
Reaction Steps
A mixture of 7-(2,3-epoxypropoxy)-2,2-dimethyl-4-phenylchroman (6.35g.), isopropylamine (16 ml) and ethanol (16 ml) was boiled under reflux for 2 days. Removal of the solvent in vacuo gave 7-(2-hydroxy-3-isopropylaminopropoxy)-2,2-dimethyl-4-phenylchroman (6.7 g., 73%) isolated as the hydrochloride salt, m.p. 171°-174° from ether-ethanol.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04093631 |
| Source dataset | uspto-grants-1978_06 |
| ORD ID | ord-6b74868ce28544f3910412ab8beb8f4e |
| Source note | uspto-grants-1978_06 |