HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methylamine → 1-((3,4-Dihydro-2,2-dimethyl-4-phenyl-2H-1-benzopyran-7-yl)oxy)-3-(methylamino)-2-propanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methylamine | HCID 6329 | — |
| Reactant | 7-(2,3-Epoxypropoxy)-2,2-dimethyl-4-phenylchroman | HCID 23330756 | — |
| Product | 1-((3,4-Dihydro-2,2-dimethyl-4-phenyl-2H-1-benzopyran-7-yl)oxy)-3-(methylamino)-2-propanol | HCID 3046432 | — |
Reaction Steps
Reaction of 7-(2,3-epoxypropoxy)-2,2-dimethyl-4-phenylchroman with methylamine by an analogous method to that described in Example 2 gave 7-(2-hydroxy-3-methylaminopropoxy)-2,2-dimethyl-4-phenylchroman isolated as its hydrochloride salt, (57%), m.p. 182°-183°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04093631 |
| Source dataset | uspto-grants-1978_06 |
| ORD ID | ord-4f7a5c441bef41a2ab4a3e8c4d9d5918 |
| Source note | uspto-grants-1978_06 |