Hydrochloric Acid → 3-[N'-formyl-N'-(3-hydroxypropyl)amino]-N,N,N-trimethyl-1-propanaminium chloride

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	Hydrochloric Acid	HCID 313	—
Edukt	Methyl iodide	HCID 6328	—
Edukt	Sodium Carbonate	HCID 10340	—
Edukt	Oxetane	HCID 10423	—
Edukt	Thionyl Chloride	HCID 24386	—
Edukt	3-[N-(3-hydroxypropyl)methylamino]-N,N,N-trimethylpropan-1-aminium chloride hydrochloride	HCID 21316367	—
Edukt	N,N,N-Trimethyl-3-(methylamino)propan-1-aminium bromide	HCID 21444211	—
Edukt	3-[N-(3-chloropropyl)methylamino]-N,N,N-trimethyl-propan-1-aminium chloride	HCID 23347575	—
Edukt	N-(3-aminopropyl)-N-(3-hydroxypropyl)formamide;hydrochloride	HCID 157229452	—
Produkt	3-[N'-formyl-N'-(3-hydroxypropyl)amino]-N,N,N-trimethyl-1-propanaminium chloride	HCID 21316369	—

Reaktionsschritte

The hydrochloride of 3-[N-(3-chloropropyl)methylamino]-N,N,N-trimethyl-propan-1-aminium chloride has been prepared by reacting thionyl chloride with 3-[N-(3-hydroxypropyl)methylamino]-N,N,N-trimethylpropan-1-aminium chloride hydrochloride. This 3-[N-(3-hydroxypropyl)methylamino]-N,N,N-trimethylpropan-1-aminium chloride hydrochloride has been prepared (a) by heating N,N,N-trimethyl-[3-(methylamino)]-1-propanaminium bromide with oxetane, and treating the resulting product with concentrated hydrochloric acid; and (b) by reacting 3-[N'-formyl-N'-(3-hydroxypropyl)amino]-1-propanamine hydrochloride with iodomethane in the presence of sodium carbonate to form 3-[N'-formyl-N'-(3-hydroxypropyl)amino]N,N,N-trimethyl-propan-1-aminium chloride, and reacting the latter with formalin in formic acid followed by concentrated hydrochloric acid.

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US04093657
Quelldatensatz	uspto-grants-1978_06
ORD ID	ord-51ba6199402540e5a4b94752ef54639b
Quellennotiz	uspto-grants-1978_06