Hydrochloric Acid → 3-[N-(3-chloropropyl)methylamino]-N,N,N-trimethyl-propan-1-aminium chloride hydrochloride

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Reaction Steps

The resulting acetonitrile solution is evaporated in vacuo, the residual crystalline material is triturated with an organic solvent, such as ether, and the crystalline material is recovered to give the monoquaternary salt, 3-[N-(3-chloropropyl)methylamino]-N,N,N-trimethyl-propan-1-aminium chloride. The latter is ordinarily converted to the hydrochloride by dissolving the 3-[N-(3-chloropropyl) methylamino]-N,N,N-trimethyl-propan-1-aminium chloride in isopropanol, adding concentrated aqueous hydrochloric acid to the resulting solution, allowing the resulting mixture to stand at room temperature until crystallization is substantially complete, and recovering the crystalline material which is washed with an organic solvent such as isopropanol to give substantially pure 3-[N-(3-chloropropyl)methylamino]-N,N,N-trimethyl-propan-1-aminium chloride hydrochloride.

Provenance & Evidence