反应详情

A solution of 13 g (0.072 mole) of 4-methyl-2-piperidinecarboxylic acid hydrochloride and 50 ml of thionyl chloride in 300 ml of ethanol was refluxed for 4 hours. At the end of this period, the solvent was evaporated under reduced pressure, and the residue was extracted with a solution of chloroform and saturated potassium carbonate solution. The chloroform layer was dried over anhydrous sodium sulfate and then chloroform was evaporated. Distillation of the residue gave 7.4 g (60%) of ethyl 4-methyl-2-piperidinecarboxylate, B.P. 76°-77° C/3 mmHg.

1. customAt the end of this period, the solvent was evaporated under reduced pressure
2. extractionthe residue was extracted with a solution of chloroform and saturated potassium carbonate solution
3. dry with materialThe chloroform layer was dried over anhydrous sodium sulfate
4. customchloroform was evaporated
5. distillationDistillation of the residue