Isopropylamine → HCID 20325505, compound

HRID 838978Notes

Reaction equation

HRID 838978 reaction equation
[O:1]1[CH2:16][CH:2]1[CH2:3][O:4][C:5]1[CH:14]=[C:13]2[C:8]([CH:9]=[N:10][NH:11][C:12]2=[O:15])=[CH:7][CH:6]=1.[CH:17]([NH2:20])([CH3:19])[CH3:18]>>[OH:1][CH:2]([CH2:16][NH:20][CH:17]([CH3:19])[CH3:18])[CH2:3][O:4][C:5]1[CH:14]=[C:13]2[C:8]([CH:9]=[N:10][NH:11][C:12]2=[O:15])=[CH:7][CH:6]=1

Participants

3

Reactant 2

HCID 6363IsopropylamineHCID 203254967-(2-Oxiranylmethoxy)-1(2H)-phthalazinone

Product 1

HCID 20325505HCID 20325505, compound

Procedure

7-(2,3-Epoxypropoxy)-1(2H)-phthalazinone was reacted with isopropylamine in a similar manner to that described in Example 1(iv) to give 7-(2-hydroxy-3-isopropylaminopropoxy)-1(2H)-phthalazinone, the hydrochloride of which had m.p. 232°-235°.

Sources & evidence

ORD record
ord-ab14fa78e91e442fb8e2deebb4ce6b41
Source dataset
uspto-grants-1978_06
Patent number
US04093725

Reaction notes

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