HCID 12668848, compound → Tioxidazole

HRID 838989Notes

Reaction equation

HRID 838989 reaction equation
[SH:1][C:2]1[CH:8]=[C:7]([O:9][CH2:10][CH2:11][CH3:12])[CH:6]=[CH:5][C:3]=1[NH2:4].[CH3:13][O:14][C:15](=[O:22])[N:16]=[C:17](SC)SC>C(O)C>[CH3:13][O:14][C:15](=[O:22])[NH:16][C:17]1[S:1][C:2]2[CH:8]=[C:7]([O:9][CH2:10][CH2:11][CH3:12])[CH:6]=[CH:5][C:3]=2[N:4]=1

Participants

4

Reactant 2

HCID 12668848HCID 12668848, compoundHCID 203255512-Amino-5-propoxybenzene-1-thiol

Product 1

HCID 72157Tioxidazole

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

In a round bottom 1 liter flask equipped with a reflux condenser, a magnetic stirrer and a heating mantle is placed 45.75 g. of 2-mercapto-4-propoxyaniline; 48.25 g. of methyl-N-[di(methylthio)-methylene]carbamate, and 250 ml absolute ethanol. This mixture is heated to boiling under an inert atmosphere of nitrogen for 12 hrs. It is then chilled and the white crystalline solid which is formed is isolated by filtration, washed with cold ethanol and dried. m.p. 178°-180° C.

Workup

  1. customIn a round bottom 1 liter flask equipped with a reflux condenser, a magnetic stirrer
  2. temperatureThis mixture is heated
  3. temperatureIt is then chilled
  4. customthe white crystalline solid which is formed
  5. customis isolated by filtration
  6. washwashed with cold ethanol
  7. customdried

Sources & evidence

ORD record
ord-d353c23cb1da41ea9ea43be9d219d8fa
Source dataset
uspto-grants-1978_06
Patent number
US04093731

Reaction notes

Loading…