Acetone → Methyl 3-amino-4-phenoxy-5-sulfamoylbenzoate

HRID 839052Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 839052
[CH3:1][O:2][C:3](=[O:24])[C:4]1[CH:9]=[C:8]([S:10](=[O:13])(=[O:12])[NH2:11])[C:7]([O:14][C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)=[C:6]([N+:21]([O-])=O)[CH:5]=1.CC(C)=O>CO.[Ni]>[CH3:1][O:2][C:3](=[O:24])[C:4]1[CH:9]=[C:8]([S:10](=[O:13])(=[O:12])[NH2:11])[C:7]([O:14][C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)=[C:6]([NH2:21])[CH:5]=1

Komponenten

5

Edukt 2

HCID 180AcetoneHCID 53854447Methyl 3-nitro-4-phenoxy-5-sulfamoylbenzoate

Produkt 1

HCID 13020993Methyl 3-amino-4-phenoxy-5-sulfamoylbenzoate

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 935NickelKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

35 g (~0.1 mol) of 3-nitro-4-phenoxy-5-sulphamylbenzoic acid methyl ester are suspended in 150 ml of methanol and are hydrogenated with Raney nickel (5-10%) in an autoclave at 40° - 50° and 100 atmospheres gauge. The precipitated amino compound is dissolved by the addition of acetone on a steambath and the Raney nickel is removed by filtration.

Aufarbeitung

  1. customthe Raney nickel is removed by filtration

Quellen und Nachweise

ORD-Eintrag
ord-c960e04788bd4f4eb1c17d56ecc41f6e
Quelldatensatz
uspto-grants-1978_06
Patentnummer
US04093735

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