Acetyl chloride → HCID 54572901, compound

HRID 839064Notes

Reaction equation

[F:1][C:2]([F:25])([F:24])[C:3]([C:9]1[CH:18]=[CH:17][C:16]2[CH2:15][CH2:14][CH2:13][CH2:12][C:11]=2[C:10]=1[NH:19][C:20]([NH:22][CH3:23])=[O:21])([OH:8])[C:4]([F:7])([F:6])[F:5].[C:26](Cl)(=[O:28])[CH3:27]>>[C:26]([O:8][C:3]([C:9]1[CH:18]=[CH:17][C:16]2[CH2:15][CH2:14][CH2:13][CH2:12][C:11]=2[C:10]=1[NH:19][C:20]([NH:22][CH3:23])=[O:21])([C:4]([F:6])([F:5])[F:7])[C:2]([F:24])([F:25])[F:1])(=[O:28])[CH3:27]

Participants

Reactant 2

HCID 6367Acetyl chloride

HCID 54229471HCID 54229471, compound

Product 1

HCID 54572901HCID 54572901, compound

Procedure

Reaction of the compounds of formulae (Ia) and (Ib) wherein Z is hydroxy with the appropriate acid chloride affords the corresponding alkanoyloxy derivative. For instance, reaction of N-[2-(hexafluoro-2-hydroxy-2-propyl)-5,6,7,8-tetrahydro-1-naphthyl]-N'-methylurea with acetyl chloride yields N-[2-(2-acetoxyhexafluoro-2-propyl)-5,6,7,8-tetrahydro-1-naphthyl]-N'-methylurea.

Sources & evidence

ORD record: ord-2bfd2bfe40ec4cc28efd3582f450b8a8
Source dataset: uspto-grants-1978_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04093742

Reaction notes

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