反应详情

To 4-amino-5-(hexafluoro-2-hydroxy-2-propyl)indan (4.2g, 14 mmole, prepared from 4-aminoindan by the procedure of Gilbert, J. Org. Chem., 30, 1001 (1965), m.p. 155°-8°) in 50 ml 4:1 Et2O-hexane add ethyl isocyanate (1.3 g, 18mmole). After 1 hour filter the solid and dry to give 4.4 g N-ethyl-N'-[5-(hexafluoro-2-hydroxy-2-propyl)-4-indanyl]urea; m.p. 142°-143° C.

1. filtrationAfter 1 hour filter the solid
2. customdry