Ethyl isocyanate → HCID 53912241, compound

HRID 839067Notes

Reaction equation

HRID 839067 reaction equation
[NH2:1][C:2]1[C:10]([C:11]([OH:20])([C:16]([F:19])([F:18])[F:17])[C:12]([F:15])([F:14])[F:13])=[CH:9][CH:8]=[C:7]2[C:3]=1[CH2:4][CH2:5][CH2:6]2.NC1C=CC=C2C=1CCC2.[CH2:31]([N:33]=[C:34]=[O:35])[CH3:32]>CCOCC.CCCCCC>[CH2:31]([NH:33][C:34]([NH:1][C:2]1[C:10]([C:11]([OH:20])([C:12]([F:13])([F:14])[F:15])[C:16]([F:17])([F:18])[F:19])=[CH:9][CH:8]=[C:7]2[C:3]=1[CH2:4][CH2:5][CH2:6]2)=[O:35])[CH3:32]

Participants

5

Reactant 3

HCID 8022Ethyl isocyanateHCID 1225694-AminoindanHCID 53637147HCID 53637147, compound

Product 1

HCID 53912241HCID 53912241, compound

Reagents, catalysts & solvents 1

HCID 21584099Diethylether hexaneSolvent

Procedure

To 4-amino-5-(hexafluoro-2-hydroxy-2-propyl)indan (4.2g, 14 mmole, prepared from 4-aminoindan by the procedure of Gilbert, J. Org. Chem., 30, 1001 (1965), m.p. 155°-8°) in 50 ml 4:1 Et2O-hexane add ethyl isocyanate (1.3 g, 18mmole). After 1 hour filter the solid and dry to give 4.4 g N-ethyl-N'-[5-(hexafluoro-2-hydroxy-2-propyl)-4-indanyl]urea; m.p. 142°-143° C.

Workup

  1. filtrationAfter 1 hour filter the solid
  2. customdry

Sources & evidence

ORD record
ord-f0c8d4d204ff4689bb44ef0caf2068f5
Source dataset
uspto-grants-1978_06
Patent number
US04093742

Reaction notes

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