Hydrochloric Acid → HCID 22563395, compound

Participants

Reaction Steps

A mixture of 2-(p-chlorophenyl)-4-isopropoxymethyl-5-methylimidazole hydrochloride (45.9 g, 0.152 mole) and 250 ml of water is stirred and refluxed. To this mixture is added 25 ml of concentrated hydrochloric acid and stirring and refluxing are continued for 6 hours. This mixture is chilled and filtered. The solid is dried in a vacuum desiccator and then recrystallized from isopropyl alcohol to give 25 g (64%) of 2-(p-chlorophenyl)-4-hydroxymethyl-5-methylimidazole hydrochloride, m.p. 181° C (dec.).

Provenance & Evidence