HRID839146

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID1883

7-Amino-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

C8H10N2O3S

HCID13729

未命名化合物

结构：CC1=C(C(=O)O)N2C(=O)C(NC(=O)C(N)c3ccc(CCl)cc3)C2SC1

HCID20325856

未命名化合物

结构：CC1=C(C(=O)OCOC(=O)C(C)(C)C)N2C(=O)C(NC(=O)C(N)c3ccc(CCl)cc3)C2SC1

HCID53843839

未命名化合物

PRODUCTS

生成物

结构：CC(=O)OCOC(=O)C1=C(C)CSC2C(N)C(=O)N12.CCCC(=O)OCOC(=O)C1=C(C)CSC2C(N)C(=O)N12

HCID70622626

未命名化合物

PROCEDURE

实验过程

When in the procedure of Example 16 an appropriate amount of 7-amino-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]-oct-2-ene-2-carboxylic acid or the corresponding pivalyloxymethyl ester is substituted for 3-[(acetyloxy)-methyl]-7-amino-8-oxo-5-thia-1azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 3-methyl-7-[[2-[4-(chloromethyl)-phenyl]-2-aminoacetyl]amino]-8-oxo-5-thia-1-azabicyclo-[4.2.0]oct-2-ene-2-carboxylic acid and 3-methyl-7-[[2-[4-(chloromethyl)phenyl]-2-aminoacetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid pivalyloxymethyl ester are obtained.

WORKUP

后处理

customare obtained

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-41469ca47a804088918fe401be82849e
来源数据集: uspto-grants-1978_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04093804
来源说明: uspto-grants-1978_06

反应 SMILES

[NH2:1][CH:2]1[C:9](=[O:10])[N:8]2[CH:3]1[S:4][CH2:5][C:6]([CH3:14])=[C:7]2[C:11]([OH:13])=[O:12].C(OCC1CSC2N(C(=O)C2N)C=1C(O)=O)(=O)C.CC1CSC2N(C(=O)C2NC(=O)C(C2C=CC(CCl)=CC=2)N)C=1C(O)=O.[C:59]([O:65][CH2:66][O:67][C:68]([C:70]1[N:71]2[CH:74]([S:75][CH2:76][C:77]=1[CH3:78])[CH:73]([NH:79]C(=O)C(C1C=CC(CCl)=CC=1)N)[C:72]2=[O:92])=[O:69])(=[O:64])[C:60](C)(C)C>>[C:68]([O:67][CH2:66][O:12][C:11]([C:7]1[N:8]2[CH:3]([S:4][CH2:5][C:6]=1[CH3:14])[CH:2]([NH2:1])[C:9]2=[O:10])=[O:13])(=[O:69])[CH2:70][CH2:77][CH3:76].[C:59]([O:65][CH2:66][O:67][C:68]([C:70]1[N:71]2[CH:74]([S:75][CH2:76][C:77]=1[CH3:78])[CH:73]([NH2:79])[C:72]2=[O:92])=[O:69])(=[O:64])[CH3:60]