反应详情

Stir 48 g of 3-(5-nitro-2-furyl)-1-phenylpyrazole-4-carboxaldehyde together with 22 g of ethyl carbazate, 5 drops of glacial acetic acid and 500 ml of ethanol for 3 hours at 60° C. Add 500 ml of water dropwise to the resulting reaction mixture at room temperature. Vacuum filter and wash the obtained precipitate with ethanol/water and with water. Dry the precipitate and then admix it with toluene at 90° C to obtain a 94% yield of 3-(5-nitro-2-furyl)-1-phenylpyrazole-4-carboxaldehyde-ethoxycarbonylhydrazone [m.p. 200° to 201° C].

1. customdropwise to the resulting reaction mixture at room temperature
2. filtrationVacuum filter
3. washwash the obtained precipitate with ethanol/water
4. customDry the precipitate
5. customat 90° C