Ethanol → HCID 178514174, compound

HRID 839217Notes

Reaction equation

HRID 839217 reaction equation
[N+:1]([C:4]1[O:8][C:7]([C:9]2[C:13]([CH:14]=O)=[CH:12][NH:11][N:10]=2)=[CH:6][CH:5]=1)([O-:3])=[O:2].[NH2:16][NH:17][C:18]([NH2:20])=[S:19].C(O)C>C(O)(=O)C.O>[N+:1]([C:4]1[O:8][C:7]([C:9]2[C:13]([CH:14]=[N:16][NH:17][C:18]([NH2:20])=[S:19])=[CH:12][NH:11][N:10]=2)=[CH:6][CH:5]=1)([O-:3])=[O:2]

Participants

6

Reactant 3

HCID 702EthanolHCID 2723789ThiosemicarbazideHCID 1785198815-(5-nitrofuran-2-yl)-1H-pyrazole-4-carbaldehyde

Product 1

HCID 178514174HCID 178514174, compoundYield 95%

Reagents, catalysts & solvents 2

HCID 176Acetic AcidCatalystHCID 962WaterSolvent

Procedure

Stir 4.14 g of 3-(5-nitro-2-furyl)-1H-pyrazole-4-carboxaldehyde together with 2.0 g. of thiosemicarbazide, 2 drops of glacial acetic acid and 40 ml of ethanol for 2 hours at 50° C and then for 4 days at room temperature. Dilute the resulting product with water to produce a 95% yield of 3-(5-nitro-2-furyl)-1H-pyrazole-4-carboxaldehyde-thiosemicarbazone [m.p. above 350° C (with decomposition)].

Sources & evidence

ORD record
ord-6ca90e380c65460691795c9397e63fcd
Source dataset
uspto-grants-1978_06
Patent number
US04093812

Reaction notes

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