HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 3-(5-nitro-2-furyl)-1H-pyrazole-4-carbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Phosphorus oxychloride | HCID 24813 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | HCID 178526569 | HCID 178526569 | — |
| Solvent | 1,2-Dichloroethane | HCID 11 | — |
| Product | 3-(5-nitro-2-furyl)-1H-pyrazole-4-carbonitrile | HCID 178510440 | 96% |
Reaction Steps
Heat Then g. of 3-(5-nitro-2-furyl)-1H-pyrazole-4-carboxaldehydeoxime together with 3.4 g of phosphorus oxychloride in 20 ml of 1,2-dichloroethane for 1 hour under reflux. To the resulting product add ice together with 50 ml of water. The adjust the pH to from 3 to 4 with sodium hydrogen carbonate and remove the formed crystals by vacuum filtration. Wash the crystals with water to obtain a 96% yield of 3-(5-nitro-2-furyl)-1H-pyrazole-4-carbonitrile [m.p. 237.5° to 239° C (from ethanol)].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04093812 |
| Source dataset | uspto-grants-1978_06 |
| ORD ID | ord-d0147a6b80da4f1aadf9c90ef54ae343 |
| Source note | uspto-grants-1978_06 |