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HRID839226

反应详情

EQUATION

反应方程式

HRID 839226 的结构方程式

REACTANTS

反应物

2
结构：O=S(=O)(O)O
HCID1118

Sulfuric acid

H2O4S

结构：N#Cc1cn(-c2ccccc2)nc1-c1ccc([N+](=O)[O-])o1
HCID20326158

3-(5-Nitrofuran-2-yl)-1-phenyl-1H-pyrazole-4-carbonitrile

C14H8N4O3

PRODUCTS

生成物

1
结构：NC(=O)c1cn(-c2ccccc2)nc1-c1ccc([N+](=O)[O-])o1
HCID20326123

3-(5-Nitrofuran-2-yl)-1-phenyl-1H-pyrazole-4-carboxamide

C14H10N4O4

收率 98%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：O
溶剂HCID962

Water

H2O

CONDITIONS

反应条件

温度
40 °C

PROCEDURE

实验过程

Add 29.4 g of 3-(5-nitro-2-furyl)-1-phenylpyrazole-4-carbonitrile to 59 ml of concentrated sulfuric acid while stirring and maintaining the temperature at 40° C for 5 hours. Pour the solution onto 500 g of ice and water. Seperate the formed precipitate by vacuum filtration and wash it with water until it is neutral to obtain a 98% yield of 3-(5-nitro-2-furyl)-1-phenylpyrazole-4-carboxamide [m.p. 236° to 238° C (from dimethylformamide/methanol)].

WORKUP

后处理

  1. customSeperate the formed precipitate
  2. filtrationby vacuum filtration
  3. washwash it with water until it