HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 3-(5-Nitro-2-furyl)-1-(2-pyridyl)pyrazole-4-carboxaldehydeoxime
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Hydroxyamine hydrochloride | HCID 443297 | — |
| Reactant | Sodium Acetate | HCID 517045 | — |
| Reactant | 3-(5-Nitrofuran-2-yl)-1-(pyridin-2-yl)-1H-pyrazole-4-carbaldehyde | HCID 20326164 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 3-(5-Nitro-2-furyl)-1-(2-pyridyl)pyrazole-4-carboxaldehydeoxime | HCID 54219955 | 99% |
Reaction Steps
Add 1.18 g of anhydrous sodium acetate and 1.0 g of hydroxylamine hydrochloride to 3.9 g of 3-(5-nitro-2-furyl)-1-(2-pyridyl)pyrazole-4-carboxaldehyde in 12 ml of dimethylformamide, whereupon the temperature of the formed mixture rises slightly. Stir the resulting mixture at room temperature for 4 hours before pouring onto ice and water to obtain a 99% yield of 3-(5-nitro-2-furyl)-1-(2-pyridyl)pyrazole-4-carboxaldehydeoxime [m.p. 234.5° to 235° C].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04093812 |
| Source dataset | uspto-grants-1978_06 |
| ORD ID | ord-288267ed953a476b90d9c5285992b199 |
| Source note | uspto-grants-1978_06 |