Diethyl Ether → HCID 20324255, compound

Participants

Reaction Steps

A solution of 20 g. of 4-hydroxy-benzphenone in 180 ml. of dry ether is added, within about 30 minutes, to a 0° C solution of 184 ml. of a 3.4 molar tetrahydrofuran solution of vinyl magnesium chloride, and the reaction mixture is stirred at the same temperature for additional 1 hour. The mixture is allowed to stand at room temperature overnight. Thereafter the mixture is poured onto ice water containing ammonium chloride. The etheral phase is separated, washed with water until neutral, dried over anhydrous magnesium sulfate, and the solvent is evaporated. 22.6 g. of crude 4-hydroxy-α-vinyl-benzhydrol are obtained. After recrystallization from a mixture of ethyl acetate and n-hexane, the product melts at 104°-105° C.

Provenance & Evidence