Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Benzoic Acid | HCID 243 | — |
| Reactant | Acetic Anhydride | HCID 7918 | — |
| Reactant | N~1~,N~1~,N~3~,N~3~-Tetraethylbenzene-1,3-diamine | HCID 19382815 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | Phthalide | HCID 6885 | 247.1% |
Reaction Steps
A mixture of 2-(4-dimethylamino)benzoyl)benzoic acid (8.07 g.), N,N,N',N'-tetraethyl-m-phenylenediamine (7.26 g.) and acetic anhydride (5 ml.) was heated (at 52° C.) during one and one-half hours. Addition of methanol (10 ml., then 15 ml.) afforded 3-(2,4-bis(diethylamino)phenyl)-3-(4-dimethylamino)phenyl)phthalide (I: X = (CH3CH2)2N, Y2 = Z4 = Z5 = Z6 = Z7 = H, Y4 = (CH3)2N) (10.92 g., m.p. 117°-119° C.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US04094877 |
|---|
| Source dataset | uspto-grants-1978_06 |
|---|
| ORD ID | ord-7b4b6f615aef4c45a966df0a5f76aa2f |
|---|
| Source note | uspto-grants-1978_06 |
|---|
