2-Pyrrolidone → 10-(1-Pyrrolin-2-YL)-2-(trifluoromethyl)phenoxazine

Beteiligte Stoffe

Reaktionsschritte

Reaction of 2-(trifluoromethyl)phenoxazine, 2-pyrrolidinone and phosphorus oxychloride according to the procedure of Example 1 provides the free base 10-(1-PYRROLIN-2-YL)-2-(TRIFLUOROMETHYL)PHENOXAZINE as a distillable oil, b.p. 140°-146° C. at 0.1 mm Hg. Conversion of the free base to the hydrochloride salt affords 10-(1-PYRROLIN-2-YL)-2-(TRIFLUOROMETHYL)PHENOXAZINE HYDROCHLORIDE, m.p. 219.5°-222.5° C. (dec.)(corr.), in a 62% overall yield by triturating with warm benzene.

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