Phosphorus oxychloride → 2-Chloro-10-(5-methyl-1-pyrrolin-2-YL)phenoxazine

Participants

Reaction Steps

Reaction of 2-chlorophenoxazine, 5-methyl-2-pyrrolidinone and phosphorus oxychloride according to the procedure of Example 1 provides the free base 2-CHLORO-10-(5-METHYL-1-PYRROLIN-2-YL)PHENOXAZINE as a distillable oil, b.p. 150°-170° C. at 0.1 mm Hg. Conversion of the free base to the hydrochloride salt affords 2-CHLORO-10-(5-METHYL-1-PYRROLIN-2-YL)PHENOXAZINE HYDROCHLORIDE, m.p. 213.5°-215.5° C., as a crystalline solid in a 34% overall yield by refluxing with benzene.

Provenance & Evidence