HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acridan → 10-(3,4,5,6-Tetrahydro-2-pyridyl)acridan
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acridan | HCID 7106 | — |
| Reactant | 2-Piperidone | HCID 12665 | — |
| Reactant | Phosphorus oxychloride | HCID 24813 | — |
| Product | 10-(3,4,5,6-Tetrahydro-2-pyridyl)acridan | HCID 70605434 | — |
Reaction Steps
Reaction of acridan, 2-piperidone and phosphorus oxychloride according to the procedure of Example 1 provides the free base 10-(3,4,5,6-TETRAHYDRO-2-PYRIDYL)ACRIDAN as a distillable oil, b.p. 145°-150° C. at 0.15 mm Hg. Conversion of the free base to the hydrochloride salt affords 10-(3,4,5,5-TETRAHYDRO-2-PYRIDYL)ACRIDAN HYDROCHLORIDE as the hemihydrate, m.p. 190.5°-192.5° C. (corr.) by trituration with hot benzene in a 19% overall yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04094981 |
| Source dataset | uspto-grants-1978_06 |
| ORD ID | ord-012374bff8a94ed2b61ca98d1508dbc6 |
| Source note | uspto-grants-1978_06 |