Acetyl chloride → N-(5-Nitropyridine-3-sulfonyl)acetamide

Participants

Reaction Steps

To 10 ml. of a 10% aqueous sodium carbonate solution of 0.5g. of 5-nitro-3-pyridinesulfonamide was added dropwise 1g. of acetyl chloride at 0° C. The mixture was stirred at room temperature for 2 hours and extracted with ethyl acetate. The extract was purified by silica gel chromatography to give 0.26g. of the desired product. m.p. 176° - 178° C.

Provenance & Evidence