Methyl chloroacetate → HCID 85924743, compound

Participants

Reaction Conditions

Reaction Steps

Into a three-neck r.b. flask, fitted with stirring assembly, thermometer, reflux condenser, and a dropping funnel were placed 10.7g (0.1M) p-toluidine, 21.7g (0.2M) methylchloroacetate, 50 ml water, and 80 ml dioxane. The solution was heated to reflux and 32g of an aqueous solution containing 8g (0.2M) sodium hydroxide was added dropwise so as to maintain the charge at a neutral pH. Addition was completed within 11/2 hours. The flask was cooled to 5° C, and the product was poured into a 4 l. beaker. Upon addition of 3 l. of water, a ppt. formed which was discarded. Extraction of the aqueous phase with chloroform and stripping the extract gave 24.6g of light-yellow solid.

Provenance & Evidence