4-Methyl-2,6-dinitrobenzoic acid → 3,5-Diamino-p-toluic acid

HRID 839441Notes

Reaction equation

HRID 839441 reaction equation
[N+:1]([C:4]1[CH:5]=[C:6]([CH3:16])[CH:7]=[C:8]([N+:13]([O-])=O)[C:9]=1[C:10]([OH:12])=[O:11])([O-])=O.[H][H]>CO.[Pd]>[NH2:1][C:4]1[CH:5]=[C:6]([CH3:16])[CH:7]=[C:8]([NH2:13])[C:9]=1[C:10]([OH:12])=[O:11]

Participants

5

Reactant 2

HCID 120522384-Methyl-2,6-dinitrobenzoic acidHCID 178418361HCID 178418361, compound

Product 1

HCID 570597123,5-Diamino-p-toluic acidYield 81%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

3,5-dinitro-p-toluic acid (10.0 gm.) is dissolved in methanol (300 ml.) and 5% palladium on charcoal (1.0 gm.) added. Reduction is carried out in a Parr apparatus for one hour at 40 psi of hydrogen. The product precipitates and the reaction mixture warmed until solution is complete. The catalyst is removed by filtration, washed with a few cc of methanol and the filtrate coold to 0°. The product precipitates in fine needles and is collected by filtration, washed with a few ml. of methanol and dried (5.95 gm., 81% yield, m.p. 218°-220° dec.). The thin layer chromatogram (Silica gel, 5% methanol in chloroform) shows the material to be homogeneous.

Workup

  1. customThe product precipitates
  2. temperaturethe reaction mixture warmed until solution
  3. customThe catalyst is removed by filtration
  4. washwashed with a few cc of methanol
  5. customto 0°
  6. customThe product precipitates in fine needles
  7. filtrationis collected by filtration
  8. washwashed with a few ml
  9. dry with materialof methanol and dried (5.95 gm., 81% yield, m.p. 218°-220° dec.)

Sources & evidence

ORD record
ord-cb01fb9ea3674c53977444be3f81c029
Source dataset
uspto-grants-1978_06
Patent number
US04095028

Reaction notes

Loading…