3-Thienylglyoxylic acid → 2-t-Butoxycarbonylmethoxyimino-2-(thien-3-yl)acetic Acid

HRID 839451Notes

Reaction equation

HRID 839451 reaction equation
[S:1]1[CH:5]=[CH:4][C:3]([C:6](=O)[C:7]([OH:9])=[O:8])=[CH:2]1.[C:11]([O:15][C:16]([CH2:18][O:19][NH2:20])=[O:17])([CH3:14])([CH3:13])[CH3:12]>C(Cl)(Cl)(Cl)Cl>[C:11]([O:15][C:16]([CH2:18][O:19][N:20]=[C:6]([C:3]1[CH:4]=[CH:5][S:1][CH:2]=1)[C:7]([OH:9])=[O:8])=[O:17])([CH3:14])([CH3:13])[CH3:12]

Participants

4

Reactant 2

HCID 17136523-Thienylglyoxylic acidHCID 12919121tert-Butyl (aminooxy)acetate

Product 1

HCID 541680482-t-Butoxycarbonylmethoxyimino-2-(thien-3-yl)acetic Acid

Reagents, catalysts & solvents 1

HCID 5943Carbon TetrachlorideSolvent

Procedure

Thien-3-ylglyoxylic acid and t-butoxycarbonylmethoxyamine were reacted as described in Preparation 1 to give the title compound, m.p. 102.6°-104.4° (from carbon tetrachloride); λmax (pH6 phosphate buffer) 258 nm (ε 13,700).

Workup

  1. customas described in Preparation 1

Sources & evidence

ORD record
ord-32fb542d016040138698baa8f99875c5
Source dataset
uspto-grants-1978_06
Patent number
US04095021

Reaction notes

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