HCID 86735750, compound → 9-Fluoro-11beta-hydroxy-17-(phenylthio)androsta-1,4,16-trien-3-one

Participants

Reaction Conditions

Reaction Steps

A suspension of 3.0 g of 9-fluoro-11β-hydroxy-17,17-bis(phenylthio)androsta-1,4-dien-3-one in 150 ml of diethylbenzene is stirred at 190° C for 45 minutes. The solution is cooled at 0° C and a solid crystallizes. This is filtered and dried in vacuo to give 2.3 g of material. Recrystallization from chloroform-methanol gives 1.1 g of the title compound, melting point 250°-251° C (dec.), with consistent spectral data.

Provenance & Evidence