HCID 86735751, compound → HCID 70463489, compound

HRID 839471Notes

Reaction equation

HRID 839471 reaction equation
[C:1]([O:4][C@H:5]1[CH2:22][C@@:20]2([CH3:21])[C@@H:16]([CH2:17][CH2:18][C:19]2(SC2C=CC=CC=2)[S:23][C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)[C@H:15]2[C@@:6]1([F:39])[C@:7]1([CH3:38])[C:12]([CH2:13][CH2:14]2)=[CH:11][C:10](=[O:37])[CH:9]=[CH:8]1)(=[O:3])[CH3:2]>C(C1C=CC=CC=1CC)C>[C:1]([O:4][C@H:5]1[CH2:22][C@@:20]2([CH3:21])[C@@H:16]([CH2:17][CH:18]=[C:19]2[S:23][C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)[C@H:15]2[C@@:6]1([F:39])[C@:7]1([CH3:38])[C:12]([CH2:13][CH2:14]2)=[CH:11][C:10](=[O:37])[CH:9]=[CH:8]1)(=[O:3])[CH3:2]

Participants

3

Reactant 1

HCID 86735751HCID 86735751, compound

Product 1

HCID 70463489HCID 70463489, compoundYield 116.2%

Reagents, catalysts & solvents 1

HCID 86571,2-DiethylbenzeneSolvent

Procedure

A solution of 11β-(acetyloxy)-17,17-bis(phenylthio)-9-fluoroandrosta-1,4-diene-3-one (2.3 g) in diethylbenzene (150 ml) is heated in a bath at 190° C for 60 minutes. The solution is then cooled in an ice bath and the separated title compound is isolated by filtration and washed with hexane to afford 2.15 g of the title compound, melting point 229°-231° C.

Workup

  1. temperatureThe solution is then cooled in an ice bath
  2. customthe separated title compound
  3. customis isolated by filtration
  4. washwashed with hexane

Sources & evidence

ORD record
ord-e3a6ebdc37a44045b5e645a99b83a127
Source dataset
uspto-grants-1978_06
Patent number
US04094840

Reaction notes

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