Formaldehyde → (+-)-Pantolactone

HRID 839474Notes

Reaction equation

HRID 839474 reaction equation
[CH2:1]=[O:2].[CH:3](=[O:7])[CH:4]([CH3:6])[CH3:5].[C-]#N.[Na+].S(=O)(=O)(O)O.[CH3:16][OH:17]>>[CH3:5][C:4]1([CH3:6])[CH:3]([OH:7])[C:16](=[O:17])[O:2][CH2:1]1

Participants

6

Reactant 5

HCID 712FormaldehydeHCID 887MethanolHCID 1118Sulfuric AcidHCID 6561IsobutyraldehydeHCID 8929Sodium Cyanide

Product 1

HCID 989(+-)-PantolactoneYield 76%

Procedure

The same apparatus and process was used as in Example 1 except as follows: The starting product comprised 5.45 l/hr. of formalin (30%), 5.35 l/hr. of isobutyraldehyde, 2.35 l/hr. of methanol, 9.25 l/hr. of NaCN solution and 12 l/hr. of sulfuric acid (46%). The latter was used in the hydrolysis step. The residence time in the circulation reactor was 20 min. The temperature in the same reactor was 5° C. The time for the aftertreatment reaction was 40 min. The temperature in the tubular reactor was 150° C. and the residence time therein was 6 min. There were obtained 7 kg pantolactone of 90% purity. The yield was 76%.

Workup

  1. customThe latter was used in the hydrolysis step
  2. customwas 5° C
  3. customThe time for the aftertreatment reaction
  4. waitwas 40 min
  5. customwas 150° C.
  6. waitthe residence time therein was 6 min

Sources & evidence

ORD record
ord-8a138cfc384440fdb18cfbed76b62429
Source dataset
uspto-grants-1978_06
Patent number
US04095952

Reaction notes

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