Chlorosuccinimide → HCID 23317233, compound

Participants

Reaction Steps

4.1 g of 1-methyl-2-chloromethyl-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepine and 1.94 g of N-chlorosuccinimide were heated under reflux in 50 ml methylenechloride for 24 hours. The solvent was then distilled off in a vacuum, the crude product was taken up in ether and reacted with an isopropanol solution of hydrogen chloride. There were obtained 3 g of 7-chloro-1-methyl-2-chloromethyl-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepine hydrochloride. The product was identical with that of Example 4.

Provenance & Evidence