HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrazine hydrate (1:1) → 6-Chloro-1,2-dihydrophthalazin-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrazine hydrate (1:1) | HCID 24654 | — |
| Reactant | Benzoic acid, 4-chloro-2-(dichloromethyl)- | HCID 11085870 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 6-Chloro-1,2-dihydrophthalazin-1-one | HCID 12298541 | 63.1% |
Reaction Steps
A solution of 23.9 g (0.1 mole) of 4-chloro-2-dichloromethylbenzoic acid and 16 g (0.32 mole) of hydrazine hydrate in 200 ml of ethanol was heated under reflux for 3 hours. The ethanol was evaporated under reduced pressure, and the residue recrystallized from ethanol to give 11.4 g (yield: 63%) of 6-chloro-1-phthalazinone having a melting point of 272°-273° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04096143 |
| Source dataset | uspto-grants-1978_06 |
| ORD ID | ord-a4c966434adc403e888707450cf3aa29 |
| Source note | uspto-grants-1978_06 |