Thionyl Chloride → HCID 22803791, compound

Participants

Reaction Steps

To a solution of 140 mg of 3β,19-diacetoxy-14β-hydroxy-17β-pivaloxy-5α-androstane in 7.0 ml of pyridine was added 0.14 ml of thionyl chloride. The mixture was left to stand under nitrogen for 40 minutes whereupon it was poured into 70 ml of an ice-water mixture. Extraction with ether followed by washing of the ethereal phase with water and evaporation at reduced pressure gave 3β,19-diacetoxy-17β-pivaloxy-5α-androst-14-ene as a resinous material which was used as the starting material in the reaction described in the following example.

Provenance & Evidence