HuagongsheHuagongshe Chemistry Print Report · For research reference only
Toluene → 3-(2,4-Bis(dimethylamino)phenyl)-3-(2-acetamido-4-(dimethylamino)phenyl)phthalide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Toluene | HCID 1140 | — |
| Reactant | N-(3-(dimethylamino)phenyl)acetamide | HCID 81988 | — |
| Reactant | 2-(2,4-Bis(dimethylamino)benzoyl)benzoic acid | HCID 20287212 | — |
| Solvent | Hexane | HCID 8058 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 3-(2,4-Bis(dimethylamino)phenyl)-3-(2-acetamido-4-(dimethylamino)phenyl)phthalide | HCID 23343375 | — |
Reaction Steps
In a manner similar to that of part B of Example 3 condensation of 2-(2,4-bis(dimethylamino)benzoyl)benzoic acid (2.4 g.) and m-(dimethylamino)acetanilide (1.42 g.) and recrystallization of part of the product from a mixture of toluene, ligroin and hexane and part from a mixture of ethyl acetate and hexane afforded 3-(2,4-bis(dimethylamino)phenyl)-3-(2-acetamido-4-(dimethylamino)phenyl)phthalide (I: X = Y4 = (CH3)2N, Y2 = CH3CONH, Z4 = Z5 = Z6 = Z7 = H) (m.p. 97°-136° C.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04096176 |
| Source dataset | uspto-grants-1978_06 |
| ORD ID | ord-4f0c3b6e45bd48a5af27055e43272438 |
| Source note | uspto-grants-1978_06 |