反应详情

A solution of 4nitro-N-(4nitrostyrylsulfonyl)benzamidine (15.0 g., 0.04 mole) and 100 ml. of 2N sodium hydroxide in 200 ml. of acetone is stirred at 25° C. for a period of 1 hr. Acetone is removed under reduced pressure, the mixture filtered and the filter cake washed with water and dried affording 8.4 g. (68% yield) of 4-nitro-N-(4-nitrostyryl)benzamidine free base, m.p. 214°-216° C. 4-Nitro-N-(4-nitrostyryl)benzamidine hydrochloride obtained in the usual manner has a melting point of 243°-244° C. (dec.). The free base taken up in methanol and acidified with isethionic acid provides 4-NITRO-N-(4-NITROSTYRYL)BENZAMIDINE ISETHIONATE, m.p. 206.5°-208° C., (corr.).

1. customAcetone is removed under reduced pressure
2. filtrationthe mixture filtered
3. washthe filter cake washed with water
4. customdried
5. customaffording 8.4 g