Hydrochloric Acid → HCID 86735771, compound

Participants

Reaction Steps

A solution of 3,4-dihydroxyphenethylamine hydrochloride (0.53 g.), N-benzyloxycarbonyl-N-(4-pyridyl)aminoacetaldehyde diethyl acetal (1.2 g.) and conc. hydrochloric acid (1 ml.) in water (6 ml.) was refluxed for 8 hours at 100° C. The reaction mixture was concentrated under reduced pressure and the crystalline residue was recrystallized from a mixture of methanol and ether to give 1-(4-pyridyl)aminomethyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline dihydrochloride monohydrate (0.8 g.), mp 172° to 176° C (dec.).

Provenance & Evidence