反应详情

温度

60 °C

A mixture of N-acetyl-N-(2-pyridyl)-aminoacetaldehyde diethyl acetal (6.0 g.), methyl iodide (25 g.) and ethanol (30 ml.) was heated for 15 hours at 60° C in a sealed tube. The reaction mixture was concentrated and water was added to the residual oil. The mixture was washed twice with ether and the aqueous layer was concentrated under reduced pressure to give oil of 1-methyl-2-[N-acetyl-N-(2,2-diethoxyethyl)-amino]-pyridinium iodide (9.0 g.).

1. concentrationThe reaction mixture was concentrated
2. additionwater was added to the residual oil
3. washThe mixture was washed twice with ether
4. concentrationthe aqueous layer was concentrated under reduced pressure