Sodium Hydroxide → 6-(Phenylsulfanyl)imidazo[1,2-a]pyridin-2-amine

HRID 839625Notes

Reaction equation

HRID 839625 reaction equation
[C:1]1([S:7][C:8]2[CH:9]=[CH:10][C:11]3[N:12]([CH:14]=[C:15]([NH:17]C(=O)C(F)(F)F)[N:16]=3)[CH:13]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[OH-].[Na+]>>[NH2:17][C:15]1[N:16]=[C:11]2[CH:10]=[CH:9][C:8]([S:7][C:1]3[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=3)=[CH:13][N:12]2[CH:14]=1

Participants

3

Reactant 2

HCID 14798Sodium HydroxideHCID 54018566HCID 54018566, compound

Product 1

HCID 124108496-(Phenylsulfanyl)imidazo[1,2-a]pyridin-2-amine

Procedure

A suspension of 0.200 g. of 6-(phenylthio) 2-(trifluoroacetamido) imidazo [1,2-a] pyridine in 1 ml. of 2.5 N aqueous sodium hydroxide is stirred for 90 minutes at room temperature. The reaction mixture is extracted with methylene chloride and the extracts are washed with water and dried over magnesium sulfate. Evaporation of the solvent yields 2-amino 6-(phenylthio) imidazo [1,2-a] pyridine, m.p. 110°-112° C.

Workup

  1. additionA suspension of 0.200 g
  2. extractionThe reaction mixture is extracted with methylene chloride
  3. washthe extracts are washed with water
  4. dry with materialdried over magnesium sulfate
  5. customEvaporation of the solvent

Sources & evidence

ORD record
ord-a65c54711ab84ee78a881bc285338261
Source dataset
uspto-grants-1978_06
Patent number
US04096264

Reaction notes

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