3-Nitro-6-phenylsulfanyl-imidazo[1,2-a]pyridine → HCID 53813641, compound

HRID 839638Notes

Reaction equation

HRID 839638 reaction equation
[N+:1]([C:4]1[N:8]2[CH:9]=[C:10]([S:13][C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)[CH:11]=[CH:12][C:7]2=[N:6][CH:5]=1)([O-])=O.[H][H]>[Pd].O1CCOCC1>[NH2:1][C:4]1[N:8]2[CH:9]=[C:10]([S:13][C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)[CH:11]=[CH:12][C:7]2=[N:6][CH:5]=1

Participants

5

Reactant 2

HCID 541282433-Nitro-6-phenylsulfanyl-imidazo[1,2-a]pyridineHCID 178418361HCID 178418361, compound

Product 1

HCID 53813641HCID 53813641, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 312751,4-DioxaneSolvent

Procedure

A solution of 0.542 gm. (0.002 mole) of 3-nitro-6-phenylthioimidazo [1,2-a] pyridine in 20 ml. of dioxane is reduced at 40 psi. under a hydrogen atmosphere with 0.500 g. of 5% palladium on carbon as catalyst. When the uptake of hydrogen is complete, the catalyst is removed by filtration. The filtrate is evaporated in vacuo to yield 3-amino-6-phenylthioimidazo [1,2-a] pyridine.

Workup

  1. customthe catalyst is removed by filtration
  2. customThe filtrate is evaporated in vacuo

Sources & evidence

ORD record
ord-cb73bf6723b443cd8381ade44e5fdcc2
Source dataset
uspto-grants-1978_06
Patent number
US04096264

Reaction notes

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